What is Ozone Therapy?
Ozone therapy is the injection of self-oxidized O2 gas as O3 into a specific area or circulatory system. Ozone entering the body soon turns into O2 gas. During this interval, enzymes that function as antioxidants in the body are stimulated in line with the reaction of ozone in the region, and these enzymes soon remain in an oxygen-rich region.
In what cases is it applied?
The range of application of ozone is very wide due to the antioxidant enzymes it triggers in the injected area. In our institution, we mostly treat chronic pain, nerve compression, wound healing, etc. It is applied in many situations such as.
Clinical Medical Ozone Therapy at İSOM Orthopedic Clinic
Medical ozone therapy at İSOM Orthopedic Clinic in Istanbul utilizes certified medical-grade O2/O3 gas mixtures generated by precision clinical ozone generators. Administered strictly according to the international guidelines established by the Madrid Declaration on Ozone Therapy, this biological modality delivers controlled hormetic oxidative stimulus.
Upon contact with biological fluids, ozone instantly reacts with polyunsaturated fatty acids and glutathione, generating lipid ozonation products (LOPs) and hydrogen peroxide (H2O2). These messengers activate the Nrf2 pathway, stimulating endogenous antioxidant enzymes including superoxide dismutase (SOD), catalase, and glutathione peroxidase.
- Major Autohemotherapy (MAH): Extracorporeal ozonation of 100-150ml autologous blood with calibrated ozone concentrations (20-40 mcg/ml) for systemic vascular and immune optimization.
- Intra-Articular Ozone Injections: Direct injection into osteoarthritic knee, hip, or shoulder joints, suppressing pro-inflammatory cytokines (IL-1b, TNF-alpha) and matrix metalloproteinases.
- Peri-Articular & Subcutaneous Infiltration: Relieves localized tendon inflammation, epicondylitis, trochanteric bursitis, and chronic myofascial trigger points.
- Rectal Insufflation: A non-invasive systemic administration method providing systemic anti-inflammatory benefits via the mesenteric circulation.
Orthopedic Indications, Micro-Circulation Enhancement, and Cellular Energetics
Ozone therapy dramatically improves micro-vascular perfusion by increasing red blood cell 2,3-diphosphoglycerate (2,3-DPG) levels, shifting the oxyhemoglobin dissociation curve to the right and promoting oxygen delivery to hypoxic musculoskeletal tissues.
In patients suffering from knee osteoarthritis, clinical trials demonstrate that intra-articular ozone reduces joint effusion, decreases visual analog scale (VAS) pain scores, and enhances functional Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) mobility scores.
- Enhanced Tissue Oxygenation: Promotes neoangiogenesis and improves capillary density in ischemic muscle tissue.
- Modulation of Immune Response: Downregulates nuclear factor kappa B (NF-kB), dampening systemic chronic low-grade inflammation.
- Synergistic Combination: Can be combined with physical therapy and PRP injections to accelerate functional orthopedic recovery.
Frequently Asked Questions About Medical Ozone Therapy in Istanbul
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